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| 15. | | XXII/15 | | Guy Self returns to Holby with a former patient, Essie's friends are determined to be as normal as possible as she endures her second round of chemotherapy, and Max makes an announcement regarding the future of Darwin. více |
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| 16. | | XXII/16 | | Essie puts on a brave face as the effects of chemo start to take a toll. Guy has lots to prove as he faces a challenging case on his first day on AAU. Jac tries to keep things professional with Kian on the ward, but he has other ideas. více |
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| 17. | | XXII/17 | | As things with Jac heat up, Kian is thrown off balance when a patient causes painful memories to resurface. Tensions run high as Louis adjusts to life in his mum's hospital, and Guy tries to make amends for last week. více |
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| 18. | | XXII/18 | | Fletch's prostrate surgery is derailed when Evie arrives with a secret that makes him question himself. Nicky is shocked to find herself treating a familiar face. více |
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| 19. | | XXII/19 | | Cameron is gutted when his performance review doesn't go to plan, and Nicky's attempt to find a life-saving treatment for Brenda puts her at odds with Jac. Essie may know something that will change her life on Keller forever. více |
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